These are still the ingredients at the heart of Syntra5. We chose them based on strong evidence that they were effective in promoting healthy blood sugar: hydroxycitric acid (HCA), chromium, and vanadium. At that time, we only included three ingredients. How did we pick our ingredients? We chose the ingredients in the original formulation for Syntra5 in 1999 with the help of a respected Seattle-based bariatric physician – himself a person with unhealthy blood sugar. As a dietary supplement, Syntra5 is unique in that it has undergone this more rigorous testing. And why is this important? Dietary supplements are subject to different regulations, and therefore do not usually have a reason to undergo double-blind testing. Double-blind studies help eliminate biases and the “placebo effect”. In a double-blind study, you guessed it: neither the researcher nor the subject know if they’re taking a placebo or an active.
You’ve heard the term “ single-blind,” which means the subject doesn’t know which one they’re taking. And when we call a researcher or subject “ blind,” we just mean that person doesn’t know who is receiving an active medication and who’s receiving a placebo. The unpredictability helps keep the test objective. In order to avoid bias from researchers or participants, a randomized study doesn’t follow a pattern administering either pill. In a study, some patients are given the placebo, and some are given the “active” subject of the test (in our case, Syntra5) without any other qualifications. Another term you probably know, the “ placebo effect”, is where a product works because a researcher or participant believes in the product, and may not be reporting their objective experience. The person taking it doesn’t know which one they’re getting. What both terms mean is simply that the substance is not active and should do nothing, while the active substance does (or doesn’t do) what it’s suspected to do.
But what does that mean? You may have heard the word “ placebo” used alternately with “sugar pill”. The “gold standard” of clinical pharmaceutical research is and continues to be what’s called a placebo-controlled, randomized double-blind study.
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